Dibenzocyclooctadiene Lignans from Artemisia sieversiana and Their Nitric Oxide Inhibitory Effects

Submitting author affiliation:
Hunan University of Chinese Medicine, Changsha, China

Beilstein Arch. 2020, 202064. https://doi.org/10.3762/bxiv.2020.64.v1

Published 26 May 2020

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Two previously undescribed dibenzocyclooctadiene lignans, named sieverlignans D–E (1-2), as well as eight known ones (3-10), were isolated from the aerial parts of Artemisia sieversiana. Their structures were elucidated from extensive spectroscopic analysis, including HRMS, NMR and circular dichroism experiments. This study is the first to report dibenzocyclooctadiene lignans in the genus Artemisia and this plant. All the compounds were evaluated for their anti-neuroinflammatory effects on the lipopolysaccharides (LPS)-induced nitric oxide production in BV-2 murine microglial cells. Compounds 1 and 6 exhibited the moderate activity with their IC50 values of 47.7 and 21.9 μM, compared to a positive control quercetin with the IC50 value of 16.0 μM.

Keywords: Artemisia sieversiana; Dibenzocyclooctadiene lignans; Sieverlignans D–E; Nitric oxide inhibitory

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Zhou, X.-D.; Chen, C.-X.; Zheng, X.-K.; Gong, L.-M.; Zeng, K.-W.; Wang, W.; Tu, P.-F. Beilstein Arch. 2020, 202064. doi:10.3762/bxiv.2020.64.v1

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