Dibenzocyclooctadiene Lignans from Artemisia sieversiana and Their Nitric Oxide Inhibitory Effects

  1. Xu-Dong ZhouORCID Logo,
  2. Chao-Xi Chen,
  3. Xi-Kang Zheng,
  4. Li-Min Gong,
  5. Ke-Wu Zeng,
  6. Wei Wang and
  7. Peng-Fei Tu

Submitting author affiliation: Hunan University of Chinese Medicine, Changsha, China

Beilstein Arch. 2020, 202064. https://doi.org/10.3762/bxiv.2020.64.v1

Published 26 May 2020

  • Preprint


Two previously undescribed dibenzocyclooctadiene lignans, named sieverlignans D–E (1-2), as well as eight known ones (3-10), were isolated from the aerial parts of Artemisia sieversiana. Their structures were elucidated from extensive spectroscopic analysis, including HRMS, NMR and circular dichroism experiments. This study is the first to report dibenzocyclooctadiene lignans in the genus Artemisia and this plant. All the compounds were evaluated for their anti-neuroinflammatory effects on the lipopolysaccharides (LPS)-induced nitric oxide production in BV-2 murine microglial cells. Compounds 1 and 6 exhibited the moderate activity with their IC50 values of 47.7 and 21.9 μM, compared to a positive control quercetin with the IC50 value of 16.0 μM.

Keywords: Artemisia sieversiana; Dibenzocyclooctadiene lignans; Sieverlignans D–E; Nitric oxide inhibitory

Supporting Information

Format: DOCX Size: 2.0 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Zhou, X.-D.; Chen, C.-X.; Zheng, X.-K.; Gong, L.-M.; Zeng, K.-W.; Wang, W.; Tu, P.-F. Beilstein Arch. 2020, 202064. doi:10.3762/bxiv.2020.64.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2020 Zhou et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)

Other Beilstein-Institut Open Science Activities