Direct transformation of Baylis Hillman adducts into molecules of interest is a crucial process, thereby allylic hydroxy protected or halogenated BH adducts are commonly preferred. Herein, we report a azidophosphonium salt catalysed (QPS) straight forward protcol for synthesising structurally demanding (E) / (Z) cinnamyl-1H-1,2,3-triazoles and halomethyl coumarins from unaltered BH adducts. Novel methodology, efficient catalyst and direct utilization of BH adducts in presence mild reaction conditions identifies the reported procedures as a powerful synthetic tool.
Keywords: Phosphonium salt, Baylis-Hillman adducts, Halomethyl coumarin, Triazolation, Organocatalyst
|Format: DOCX||Size: 2.6 MB||Download|
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Karthikeyan, S.; Shobana, R.; Subimol, K. R.; Ratna Monica, J. H.; Krishna Kumar, A. K. Beilstein Arch. 2020, 202038. doi:10.3762/bxiv.2020.38.v1
|Download RIS (Reference Manager)||Download BIB (BIBTEX)|