The present communication describes the solvent and catalyst free synthesis of imidazo[1,2-a]pyridines in excellent to nearly quantitative yields from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25-30 °C for 3-5 min. This green strategy has several noteworthy advantages such as wide spread substrate scope, short reaction times, water work up and the products do not require any chromatographic purification. Further, it is simple to perform, highly economical and therefore the process is easy to scale up.
Keywords: 2-aminopyridines; ω-bromomethylketones; imidazo[1,2-a]pyridines; solvent and catalyst free; grindstone chemistry
When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Godugu, K.; Nallagondu, C. G. R. Beilstein Arch. 2020, 202033. doi:10.3762/bxiv.2020.33.v1
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