Solvent and catalyst free synthesis of imidazo[1,2-a]pyridines by grindstone chemistry

Submitting author affiliation:
Yogi Vemana University, Kadapa, India

Beilstein Arch. 2020, 202033.

Published 26 Mar 2020

This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


The present communication describes the solvent and catalyst free synthesis of imidazo[1,2-a]pyridines in excellent to nearly quantitative yields  from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25-30 °C for 3-5 min. This green strategy has several noteworthy advantages such as wide spread substrate scope, short reaction times, water work up and the products do not require any chromatographic purification. Further, it is simple to perform, highly economical and therefore the process is easy to scale up.

Keywords: 2-aminopyridines; ω-bromomethylketones; imidazo[1,2-a]pyridines; solvent and catalyst free;  grindstone chemistry

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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Godugu, K.; Nallagondu, C. G. R. Beilstein Arch. 2020, 202033. doi:10.3762/bxiv.2020.33.v1

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