Beilstein Arch. 2020, 202033. https://doi.org/10.3762/bxiv.2020.33.v1
Published 26 Mar 2020
The present communication describes the solvent and catalyst free synthesis of imidazo[1,2-a]pyridines in excellent to nearly quantitative yields from 2-aminopyridines and a wide variety of ω-bromomethylketones using a grindstone procedure at 25-30 °C for 3-5 min. This green strategy has several noteworthy advantages such as wide spread substrate scope, short reaction times, water work up and the products do not require any chromatographic purification. Further, it is simple to perform, highly economical and therefore the process is easy to scale up.
Keywords: 2-aminopyridines; ω-bromomethylketones; imidazo[1,2-a]pyridines; solvent and catalyst free; grindstone chemistry
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Godugu, K.; Nallagondu, C. G. R. Beilstein Arch. 2020, 202033. doi:10.3762/bxiv.2020.33.v1
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and
Zotero.
© 2020 Godugu and Nallagondu; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)
