Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers mediated by a reaction between phenols and halothane

  1. Yukiko Karuo,
  2. Ayaka Kametani,
  3. Atsushi Tarui,
  4. Kazuyuki SatoORCID Logo,
  5. Kentaro Kawai and
  6. Masaaki OmoteORCID Logo

Submitting author affiliation: Setsunan University, Nagaotoge-cho, Hirakata city, Japan

Beilstein Arch. 2020, 202021.

Published 19 Feb 2020

  • Preprint


An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibited a broad reaction scope, simple operation, and no need for any expensive transition-metal catalysts, or highly toxic reagents. Notably, we demonstrated the potential utility of halothane for obtaining such aryl gem-difluoroalkyl ethers containing a bromochloromethyl group.

Keywords: aryl 1,1-difluoroethyl ether; 1,1-difluoroethene; fluorine compound; halothane; phenol.

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Karuo, Y.; Kametani, A.; Tarui, A.; Sato, K.; Kawai, K.; Omote, M. Beilstein Arch. 2020, 202021. doi:10.3762/bxiv.2020.21.v1

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