An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibited a broad reaction scope, simple operation, and no need for any expensive transition-metal catalysts, or highly toxic reagents. Notably, we demonstrated the potential utility of halothane for obtaining such aryl gem-difluoroalkyl ethers containing a bromochloromethyl group.
Keywords: aryl 1,1-difluoroethyl ether; 1,1-difluoroethene; fluorine compound; halothane; phenol.
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Karuo, Y.; Kametani, A.; Tarui, A.; Sato, K.; Kawai, K.; Omote, M. Beilstein Arch. 2020, 202021. doi:10.3762/bxiv.2020.21.v1
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