Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers mediated by a reaction between phenols and halothane

  1. Yukiko Karuo,
  2. Ayaka Kametani,
  3. Atsushi Tarui,
  4. Kazuyuki SatoORCID Logo,
  5. Kentaro Kawai and
  6. Masaaki OmoteORCID Logo

Submitting author affiliation: Setsunan University, Nagaotoge-cho, Hirakata city, Japan

Beilstein Arch. 2020, 202021. https://doi.org/10.3762/bxiv.2020.21.v1

Published 19 Feb 2020

  • Preprint

Abstract

An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibited a broad reaction scope, simple operation, and no need for any expensive transition-metal catalysts, or highly toxic reagents. Notably, we demonstrated the potential utility of halothane for obtaining such aryl gem-difluoroalkyl ethers containing a bromochloromethyl group.

Keywords: aryl 1,1-difluoroethyl ether; 1,1-difluoroethene; fluorine compound; halothane; phenol.

Supporting Information

Format: DOCX Size: 4.1 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Karuo, Y.; Kametani, A.; Tarui, A.; Sato, K.; Kawai, K.; Omote, M. Beilstein Arch. 2020, 202021. doi:10.3762/bxiv.2020.21.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2020 Karuo et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)

Other Beilstein-Institut Open Science Activities

Logo
Logo
Logo
Symposia