A new, mild and efficient protocol for the synthesis of trifluoromethyl-indolyl-phenylethanols by the reaction of indoles with a variety of aromatic fluoromethyl ketones in the presence of K2CO3 (15 mol%) and nBu4PBr (15 mol%) in water. The desired products were obtained in good to excellent yields without requiring the column chromatography purification. The reusability of the catalytic system and large-scale synthesis of indolyl-phenylethanols, which would further transform into biological active indole-derived compounds, are further advantages of this protocol.
Keywords: Indole, Friedel-Crafts reaction, C-C-bond formation, C3-funtionalization of indole, indole-3-carbinol, diindolylmethane, recyclability and large-scale synthesis
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Pillaiyar, T.; Sedaghati, M.; Schnakenburg, G. Beilstein Arch. 2020, 202017. doi:10.3762/bxiv.2020.17.v1
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