Synthesis of 1-Indolyl-3,5,8-Substituted γ-Carbolines: One Pot Metal-Solvent Free Protocol and Biological Evaluation

Submitting author affiliation:
Indian Institute of Technology Indore, Indore, India

Beilstein Arch. 2020, 2020131.

Published 19 Nov 2020

cc-by Logo
This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


1,5-Disubstituted indole-2-carboxaldehyde derivatives (1ah) and glycine alkyl esters (2ac) are shown to undergo a novel cascade imination-heterocylisation in the presence of organic base DIPEA to provide 1-indolyl 3,5,8-substituted g-carbolines (3aaea) in good yields. The g-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin and kidney cancers.

Keywords: γ-Carboline; cascade reaction; cytotoxicity; cell uptake; density functional theory; fluorescence.

Supporting Information

Format: DOCX Size: 16.0 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Dudhe, P.; Krishnan, M. A.; Yadav, K.; Roy, D.; Venkatasubbaiah, K.; Pathak, B.; Chelvam, V. Beilstein Arch. 2020, 2020131. doi:10.3762/bxiv.2020.131.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.