1,5-Disubstituted indole-2-carboxaldehyde derivatives (1a–h) and glycine alkyl esters (2a–c) are shown to undergo a novel cascade imination-heterocylisation in the presence of organic base DIPEA to provide 1-indolyl 3,5,8-substituted g-carbolines (3aa–ea) in good yields. The g-carbolines are fluorescent and exhibit anticancer activities against cervical, lung, breast, skin and kidney cancers.
Keywords: γ-Carboline; cascade reaction; cytotoxicity; cell uptake; density functional theory; fluorescence.
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Dudhe, P.; Krishnan, M. A.; Yadav, K.; Roy, D.; Venkatasubbaiah, K.; Pathak, B.; Chelvam, V. Beilstein Arch. 2020, 2020131. doi:10.3762/bxiv.2020.131.v1
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