Beilstein Arch. 2020, 2020123. https://doi.org/10.3762/bxiv.2020.123.v1
Published 28 Oct 2020
A novel synthetic approach to the preparation of N-aryl substituted azacycles from N-allyl and N-tert-butyl protected arylamines is described. In this preparation, a metal free reagent system utilizing POCl3 and TBD proved to be an important contributor for reactions of N-allyl- and tert-butyl-protected aryamines with cyclic ethers to generate the target azacycles. This protocol provides a practical approach to high yield, direct synthesis of N-aryl substituted five-membered and six-membered azacycles from N-allyl arylamines and N-tert-butyl arylamines
Keywords: Azacycles; N–allyl arylamines; N–tert-butyl arylamines; Direct Transformation; Cyclic ethers.
| Format: DOCX | Size: 3.7 MB | Download |
When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:
Tran, V. H.; Hong, W. P.; Kim, H.-K. Beilstein Arch. 2020, 2020123. doi:10.3762/bxiv.2020.123.v1
Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and
Zotero.
© 2020 Tran et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)
