Beilstein Arch. 2019, 201998. https://doi.org/10.3762/bxiv.2019.98.v1
Published 03 Sep 2019
A simple and efficient procedure for the separation of cis-(+)- and cis-(−)-4-O-protected-cyclopent-2-enol, from the corresponding racemic mixture as starting material and using resolving agents, is described. The separation of diasteroisomers was accomplished by flash silica gel column chromatography. The enantiomers cis-(+)- and cis-(−)- of 4-O-protected-cyclopent-2-enol were obtained, in enantiomeric pure form, after elimination of the resolving agents.
Keywords: cis-4-O-TBS-cyclopent-2-enol • chiral building blocks • resolving agents • chemical desymmetrization • (R)-(+)-O-mandelic acid
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Sidi Mohamed, B.; Peyrottes, S.; Uttaro, J.-P.; MATHE, C. Beilstein Arch. 2019, 201998. doi:10.3762/bxiv.2019.98.v1
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