Design, synthesis and investigation of water-soluble hemi‑indigo photoswitches for bioapplications

Submitting author affiliation:
Universität Siegen, Siegen, Germany

Beilstein Arch. 2019, 201995.

Published 02 Sep 2019

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A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomolecules. The synthetic approach towards the introduction of the alkylamino pendant to the dimethoxy hemi-indigo core was developed that allowed to obtain an RNA-binding hemi-indigo derivative with photoswitchable fluorescent properties.

Keywords: hemi-indigo; photochromism; photoswitching; visible light; water solubility

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Berdnikova, D. V. Beilstein Arch. 2019, 201995. doi:10.3762/bxiv.2019.95.v1

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