Design, synthesis and investigation of water-soluble hemi‑indigo photoswitches for bioapplications

  1. Daria V. BerdnikovaORCID Logo

Submitting author affiliation: Universität Siegen, Siegen, Germany

Beilstein Arch. 2019, 201995.

Published 02 Sep 2019

  • Preprint


A series of hemi-indigo derivatives was synthesized and their photoswitching properties in aqueous medium were studied. The dimethoxy hemi-indigo derivative with the best photochromic performance in water was identified as a promising platform for the development of photoswitchable binders for biomolecules. The synthetic approach towards the introduction of the alkylamino pendant to the dimethoxy hemi-indigo core was developed that allowed to obtain an RNA-binding hemi-indigo derivative with photoswitchable fluorescent properties.

Keywords: hemi-indigo; photochromism; photoswitching; visible light; water solubility

Supporting Information

Format: PDF Size: 1.5 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Berdnikova, D. V. Beilstein Arch. 2019, 201995. doi:10.3762/bxiv.2019.95.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2019 Berdnikova; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License ( Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (

Other Beilstein-Institut Open Science Activities