Skeletocutins M-Q, biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa  

Submitting author affiliation:
Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany

Beilstein Arch. 2019, 201974.

Published 22 Jul 2019

cc-by Logo


During the course of screening for new metabolites from basidiomycetes, we isolated and characterized five previously undescribed secondary metabolites skeletocutins M-Q (1-5) along with the known metabolite tyromycin A (6) from the fruiting bodies of the polypore Skeletocutis sp. The new compounds did not exhibit any antimicrobial, cytotoxic or nematicidal activities. However, compound 3 moderately inhibited the biofilm formation of Staphylococcus aureus, while compounds 3 and 4 performed moderately activity in the L-leucine-7-amido-4-methylcoumarin (L-Leu-AMC) inhibition assay. These compounds represent the first report of secondary metabolites occurring in the fruiting bodies of Skeletocutis. Interestingly, tyromycin A was found to be the only common metabolites in fruiting bodies and mycelial cultures of the fungus, and none of the recently reported skeletocutins from the culture of the same strain was detected in the basidiomes.

Keywords: Polyporaceae; secondary metabolites; basidiomycete; structure elucidation

Supporting Information

Format: PDF Size: 1.4 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Cheng, T.; Chepkirui, C.; Decock, C.; Matasyoh, J. C.; Stadler, M. Beilstein Arch. 2019, 201974. doi:10.3762/bxiv.2019.74.v1

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.