Palladium-catalyzed Conia-ene Reaction of 1-alkynylindolin-3-ones: a strategy for the construction of Pyrrolo[1,2-a]indoles

  1. Yong-Qin Tang,
  2. Xing-Hai Fei,
  3. Jian-Xiong An,
  4. Fen-Fen Yang,
  5. Dong-Zhu Duan,
  6. Zuo-Xian Cao,
  7. Xiao-Zhong Fu,
  8. Yuan-Yong Yang,
  9. Bin He and
  10. Yong-Long Zhao ORCID Logo

Submitting author affiliation: Guizhou Medical University, Guiyang, China

Beilstein Arch. 2019, 201959. doi:10.3762/bxiv.2019.59.v1

Published 04 Jul 2019

  • Preprint

Abstract

A palladium-catalyzed conia-ene reaction of 1-alkynylindolin-3-ones has been developed. Three examples of pyrrolo[1,2-a]indoline derivatives were readily obtained with yields up to 82% utilizing this strategy. Importantly, this palladium-catalyzed intramolecular cyclization process represents an important contribution to the application of indole-3-one derivatives.

Keywords: indolin-3-ones; Conia-ene reaction; palladium catalysis; pyrrolo[1,2-a]indoline; 1-alkynylindolin-3-ones

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When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Tang, Y.-Q.; Fei, X.-H.; An, J.-X.; Yang, F.-F.; Duan, D.-Z.; Cao, Z.-X.; Fu, X.-Z.; Yang, Y.-Y.; He, B.; Zhao, Y.-L. Beilstein Arch. 2019, 201959. doi:10.3762/bxiv.2019.59.v1

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