Synthesis and Anti-Proliferative Effect of Linalool propionate Loaded Carbon Nanoparticles

  1. Gayathri P. Kothandaraman ORCID Logo,
  2. K. Sathish Kumar,
  3. Nikhishaa Sree R.,
  4. J. Rithika and
  5. S. Dhanasree

Submitting author affiliation: VEL TECH HIGH TECH DR RANGARAJAN DR SAKUNTHALA ENGINEERING COLLEGE, avadi, India

Beilstein Arch. 2019, 201956. doi:10.3762/bxiv.2019.56.v1

Published 01 Jul 2019

  • Preprint

Abstract

The essential oils (EOs) extracted from plants hold many medicinal properties. But the delivery of the EOs and maintenance of its stability is a challenge. In this study, a linalool associated compound isolated from Coriander sativum was conjugated with carbon nanoparticle (CNP). The conjugate was characterized by Fourier transform Infrared spectroscopy (FTIR), transmission electron microscope (TEM), and particle size (PS) analysis. The nano-sized conjugate showed similar antioxidant and anti-proliferative activity when compared to the pure extract. In the case of antibacterial property, conjugate showed good inhibition against both gram-positive and gram-negative bacteria whereas the extract showed inhibition only against gram-negative bacteria. In short, the activity of the compound was not altered by its conjugation with CNP. This conjugated compound was completely water soluble which shall make it a likely formulation for hydrophilic based drug delivery applications.

Keywords: Carbon nanoparticle, Linalool, Coriander sativum, MTT assay, DPPH assay, antibacterial.

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When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Kothandaraman, G. P.; Sathish Kumar, K.; Sree R., N.; Rithika, J.; Dhanasree, S. Beilstein Arch. 2019, 201956. doi:10.3762/bxiv.2019.56.v1

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