A protocol of SO2F2 mediated installation of sulfonyl fluoride onto primary amide was developed providing a new portal to sulfur(VI) fluoride exchange (SuFEx) click chemistry. The generated molecules contain pharmaceutically important amide and -SO2F moieties for application in discovery of new therapeutics.
Keywords: N-fluorosulfonyl amides; Sulfuryl fluoride (SO2F2); primary amides
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Liu, J.; Wang, S.-M.; Qin, H.-L. Beilstein Arch. 2019, 201933. doi:10.3762/bxiv.2019.33.v1
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