Installation of sulfonyl fluorides onto primary amides

  1. Jing Liu,
  2. Shi-Meng Wang and
  3. Hua-Li QinORCID Logo

Submitting author affiliation: Wuhan University of Technology, Wuhan, China

Beilstein Arch. 2019, 201933. doi:10.3762/bxiv.2019.33.v1

Published 29 May 2019

  • Preprint


A protocol of SO2F2 mediated installation of sulfonyl fluoride onto primary amide was developed providing a new portal to sulfur(VI) fluoride exchange (SuFEx) click chemistry. The generated molecules contain pharmaceutically important amide and -SO2F moieties for application in discovery of new therapeutics.

Keywords: N-fluorosulfonyl amides; Sulfuryl fluoride (SO2F2); primary amides

Supporting Information

Format: CIF Size: 14.6 KB Download
Format: DOCX Size: 1.9 MB Download
Format: PDF Size: 212.2 KB Download

How to Cite

When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Liu, J.; Wang, S.-M.; Qin, H.-L. Beilstein Arch. 2019, 201933. doi:10.3762/bxiv.2019.33.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2019 Liu et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License ( Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (

Other Beilstein-Institut Open Science Activities