Total synthesis of 2'-O-methyl-β-L-arabinosyluridine and reassignment the nucleoside from Penicillium sp. as 2'-O-methyl-β-L-uridine

Submitting author affiliation:
Jiangxi Science & Technology Normal University, Nanchang, China

Beilstein Arch. 2019, 2019128.

Published 23 Oct 2019

This preprint has not been peer-reviewed. When a peer-reviewed version is available, this information will be updated.


In order to validate the structure of a rarely reported naturally occurring nucleoside isolated from the broth of Penicillium sp. (NO. 64), practical syntheses of 2'-O-methyl-β-L-arabinosyluridine, 2'-O-methyl-α-L-arabinosyluridine, and 2'-O-methyl-β-L-uridine were accomplished. Comparing their nuclear magnetic resonance (NMR) spectra and physical data, its structure was reassigned as 2'-O-methyl-β-L-uridine instead of former reported 2'-O-methyl-β-L-arabinosyluridine.


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When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

shen, C.; Ding, H.; Tao, X.; Yang, R.; Bai, J.; Cao, B.; Peng, Y.; Xiao, Q. Beilstein Arch. 2019, 2019128. doi:10.3762/bxiv.2019.128.v1

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