Co-Catalyzed Oxidative Alkylation between Styrenes and Cyclic Ethers via sp3 C−H Functionalization

  1. Rongxiang ChenORCID Logo,
  2. Kai-Kai Wang,
  3. Zhan-Yong Wang,
  4. Xueji Ma,
  5. Doudou Wang,
  6. An-an Zhang and
  7. Lantao LiuORCID Logo

Submitting author affiliation: Xinxiang University, Xinxiang, China

Beilstein Arch. 2019, 2019119.

Published 09 Oct 2019

  • Preprint


A new cobalt-catalyzed oxidative alkylation from readily available styrenes and ethers has been disclosed for a rapid and highly efficient construction of C−C bond via sp3 C−H bond functionalization. This methodology was demonstrated by good yields and functional group compatibility with simple operation, easily available starting materials, low catalyst loadings, and mild aerobic conditions.

Keywords: cobalt; oxidative alkylation; styrene; cyclic ether; sp3 C−H functionalization

Supporting Information

Format: DOCX Size: 2.5 MB   Download

How to Cite

When a peer-reviewed version of this preprint is available, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Chen, R.; Wang, K.-K.; Wang, Z.-Y.; Ma, X.; Wang, D.; Zhang, A.-a.; Liu, L. Beilstein Arch. 2019, 2019119. doi:10.3762/bxiv.2019.119.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2019 Chen et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License ( Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (

Other Beilstein-Institut Open Science Activities