Synthesis, structural characterization and biological activity of new pyrazolo[4,3-e][1,2,4]triazine acyclonucleosides

  1. Mariusz Mojzych ORCID Logo,
  2. Zbigniew KarczmarzykORCID Logo,
  3. Joanna Matysiak and
  4. Andrzej Fruziński

Submitting author affiliation: Siedlce University of Natural Sciences and Humanities,, Siedlce, Poland

Beilstein Arch. 2019, 2019102. doi:10.3762/bxiv.2019.102.v1

Published 09 Sep 2019

  • Preprint

Abstract

A series of new pyrazolo[4,3-e][1,2,4]triazine acyclonucleosides 2-5 and 8 were prepared and evaluated for their anticancer activity against human cancer cell lines (MCF-7, K-562) and CDK2/E as well as Abl protein kinases inhibitors. Lipophilicity of the compounds was determined using C-18 and IAM chromatography. In order to confirm molecular structures and synthesis pathway of new acyclonucleosides X-ray analysis was performed for model compound 3. Theoretical calculations at DFT/B3LYP/6-311++G(d,p) level were used for characterization electronic structures of 18. The potential antiviral activity of acyclonucleoside 28 was tested in silico using molecular docking method.

Keywords: Acyclonucleosides, Pyrazolo[4,3-e][1,2,4]triazine, Anticancer activity, X-ray analysis, Theoretical calculation, Molecular docking

Supporting Information

Format: DOC Size: 5.6 MB Download

How to Cite

When a peer-reviewed version of this preprint is available in the Beilstein Journals, this information will be updated in the information box above. If no peer-reviewed version is available, please cite this preprint using the following information:

Mojzych, M.; Karczmarzyk, Z.; Matysiak, J.; Fruziński, A. Beilstein Arch. 2019, 2019102. doi:10.3762/bxiv.2019.102.v1

Download Citation
Download RIS (Reference Manager) Download BIB (BIBTEX)

© 2019 Mojzych et al.; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited.
The license is subject to the Beilstein Archives terms and conditions: (https://www.beilstein-archives.org/xiv/terms)

Other Beilstein-Institut Open Science Activities

Logo
Logo
Logo
Symposia