Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors

• Pshtiwan S. Mohammed,
• Mohammed K. S. Dalo,
• Onur C. Yazıcı,
• Muhammet Yildirim and
• Akın Sağırlı

Beilstein J. Org. Chem. 2026, 22, 1033–1047, doi:10.3762/bjoc.22.82

• validate their therapeutic potential. Keywords: aldoxime; antiparkinson; 1,3-dipolar cycloaddition; isoxazoline; 1,2,4-oxadiazoles; Introduction 1,2,4-Oxadiazoles are pharmacologically significant five-membered heterocyclic rings, primarily recognized for their bioisosteric relationship with ester and