Design, synthesis and biological evaluation of 2,5-diaryloxazolo[4,5-d]pyrimidin-7-ylamines as selective cytotoxic agents against HeLa cells

• Maryna V. Kachaeva,
• Agnieszka B. Olejniczak,
• Marta Denel-Bobrowska,
• Victor V. Zhirnov,
• Yevheniia S. Velihina,
• Stepan G. Pilyo and
• Volodymyr S. Brovarets

Beilstein J. Org. Chem. 2026, 22, 390–398, doi:10.3762/bjoc.22.27

• , 7, and 9 were selective against the tested lines. Compound 9 can be classified as the most attractive and promising candidate for further development against cervical adenocarcinoma. Keywords: ADMET analysis; anticancer activity; 2,5-diaryloxazolo[4,5-d]pyrimidin-7-ylamines; Introduction Purine

• compounds was anywhere near the activity of paclitaxel against HeLa cells (SI = 2733.50). ADMET analysis ADMET (absorption, distribution, metabolism, excretion, toxicity) analysis performed among active in vitro anticancer compounds allows to identify the most promising agents to be sent to further stages

• platforms. Pharmacokinetic properties ADMET analysis enables the prediction of a compound's pharmacokinetic profile, which is crucial for assessing its pharmacodynamic activity. The predicted pharmacokinetic properties of compounds 1, 7 and 9 are given in Table 2. For human intestinal absorption, the