Cone p-aminocalix[4]arenes enriched with ‘clickable’ alkyne or azide functionalities

• Ilia Korniltsev,
• Vasily Bazhenov,
• Alexander Gorbunov,
• Dmitry Cheshkov,
• Stanislav Bezzubov,
• Vladimir Kovalev and
• Ivan Vatsouro

Beilstein J. Org. Chem. 2026, 22, 399–415, doi:10.3762/bjoc.22.28

• virtually any functional units attached to them via triazole groups. Keywords: calixarene amines; dimeric capsules; functionalization; tetraureacalixarenes; triazoles; Introduction Considered generally as multifunctional molecular cores, calixarenes in their native forms as cyclic oligophenols actually

• pairs of distal triazole groups, and C4v-symmetric tetraureas 47 and 50. Due to the phenomenon of supramolecular chirality caused by the direction of hydrogen bonds in the capsules [100], tetraureacalixarenes of the first type should form two regioisomeric homodimers possessing C1-symmetry or a single

• heterodimer with a C4v-symmetric tetratosylureacalix[4]arene 52 (each as a pair of enantiomers). Similarly, the C2v-symmetric tetraureacalixarenes of the second type should furnish C2-symmetric homo- or heterodimers as single regioisomers (each as a pair of enantiomers), whereas homo- and heterodimers formed