Beilstein J. Org. Chem.2026,22, 1114–1121, doi:10.3762/bjoc.22.90
constants and NOESY data, and comparison of their electronic circular dichroism (ECD) spectra. Compounds 1 and 3 exhibited moderate to weak antibacterial activity against Escherichia coli at 100 μg/mL.
Keywords: Amycolatopsis sp.; indole N-glycosides; SF-2140; structurereassignment; sugarnitriles
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Graphical Abstract
Figure 1:
Structures of SF-2140 (1), sugarnitriles A (2) and B (3).
Beilstein J. Org. Chem.2026,22, 455–460, doi:10.3762/bjoc.22.33
were published or without knowledge of these results. The structurereassignment of compound 968 should aid in medicinal chemistry efforts around this scaffold with increased potency and improved pharmacological properties.
Experimental
General
X-ray data were obtained on a Bruker Smart Breeze CCD
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Graphical Abstract
Figure 1:
The glutaminase enzymes GLS1 and GLS2 catalyze the hydrolysis of glutamine to glutamate and ammonia...