Novel macrocycles: from synthesis to supramolecular function

• Veronica Iuliano,
• Carmen Talotta,
• Margherita De Rosa,
• Paolo Della Sala,
• Konrad Tiefenbacher,
• Pablo Ballester and
• Carmine Gaeta

Beilstein J. Org. Chem. 2026, 22, 982–985, doi:10.3762/bjoc.22.76

• cells. In addition to its intrinsic biological activity, the nanoassembled platform may also serve as a carrier for combination therapies by encapsulating additional therapeutic agents. Macrocyclic chemistry is proving equally vital for environmental sustainability and separation science. For instance

• application potential of macrocyclic chemistry, their further development relies on access to versatile and selectively functionalizable scaffolds. In this context, Vatsouro and co-workers [40] report efficient methodologies for accessing heteromultifunctional calix[4]arene derivatives. Through carefully

• versatile tools for the selective modulation of biologically relevant protein–protein interactions. The contributions collected in this thematic issue highlight the breadth and continued evolution of contemporary macrocyclic chemistry. From new ultracycle receptors to functional materials for carbon dioxide

Novel macrocycles – and old ones doing new tricks

• Wei Jiang and
• Christoph A. Schalley

Beilstein J. Org. Chem. 2019, 15, 1838–1839, doi:10.3762/bjoc.15.178

• special issue in the Beilstein Journal of Organic Chemistry gathers world-renowned experts in the field to share their very recent results and will surely help stimulate macrocyclic chemistry. Wei Jiang and Christoph A. Schalley Shenzhen, Berlin, July 2019

Strong binding and fluorescence sensing of bisphosphonates by guanidinium-modified calix[5]arene

• Jie Gao,
• Zhe Zheng,
• Lin Shi,
• Si-Qi Wu,
• Hongwei Sun and
• Dong-Sheng Guo

Beilstein J. Org. Chem. 2018, 14, 1840–1845, doi:10.3762/bjoc.14.157

• BPs in buffer solution, and more importantly, in artificial urine. Calibration lines were therefore set up in untreated artificial urine, allowing for quantifying the concentrations of BPs in the biologically relevant low range. Keywords: bisphosphonate; calixarene; fluorescence sensing; macrocyclic

• chemistry; indicator displacement assay; Introduction Bisphosphonates (BPs) are a kind of drugs characterized by the −C(PO3)2 group (Scheme 1a) for treating various types of bone disorders and calcium metabolic diseases [1]. They are widely used in the treatment of osteoporosis, osteitis deformans

Self and directed assembly: people and molecules

• Tony D. James

Beilstein J. Org. Chem. 2016, 12, 391–405, doi:10.3762/bjoc.12.42

• be very memorable – one such moment was being confronted by Shinkai Sensei with a bottle of champagne to celebrate that our chiral discriminating system had just been accepted for publication in Nature [33] (Figure 5b). At the 20th International Symposium on Macrocyclic Chemistry [34] in 1995, it was