Discovery of sugarnitriles A and B, and structural reassignment of SF-2140, from a sugarcane endophytic actinomycete Amycolatopsis sp. JS-O27

• Qiuyun Li,
• Ying Liu,
• Baoyue Wei,
• Yu Sun,
• Di Mao,
• Yanmin Zou and
• Shan Lu

Beilstein J. Org. Chem. 2026, 22, 1114–1121, doi:10.3762/bjoc.22.90

• Qiuyun Li Ying Liu Baoyue Wei Yu Sun Di Mao Yanmin Zou Shan Lu School of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China 10.3762/bjoc.22.90 Abstract Three rare cyano-substituted indole N-glycosides, SF-2140 (1) and its two previously undescribed derivatives, sugarnitriles A

• constants and NOESY data, and comparison of their electronic circular dichroism (ECD) spectra. Compounds 1 and 3 exhibited moderate to weak antibacterial activity against Escherichia coli at 100 μg/mL. Keywords: Amycolatopsis sp.; indole N-glycosides; SF-2140; structure reassignment; sugarnitriles

• characterized [18][19][20][21][22][23][24][25][26][27]. SF-2140, an indole alkaloid featuring an indole N-glycoside skeleton with a cyano group, was first identified from Actinomadura sp. in 1984 [19]. In 1989, the total synthesis of SF-2140 was achieved, further confirming its structure [28]. Preliminary