Discovery of sugarnitriles A and B, and structural reassignment of SF-2140, from a sugarcane endophytic actinomycete Amycolatopsis sp. JS-O27

• Qiuyun Li,
• Ying Liu,
• Baoyue Wei,
• Yu Sun,
• Di Mao,
• Yanmin Zou and
• Shan Lu

Beilstein J. Org. Chem. 2026, 22, 1114–1121, doi:10.3762/bjoc.22.90

• (2) and B (3), were isolated from a sugarcane endophytic actinomycete Amycolatopsis sp. JS-O27. The planar structures of 1–3 were established by HRESIMS data and detailed 1D/2D NMR spectroscopic analysis, and the conformations of the sugar moieties were deduced by the analysis of 3JH-H coupling

• constants and NOESY data, and comparison of their electronic circular dichroism (ECD) spectra. Compounds 1 and 3 exhibited moderate to weak antibacterial activity against Escherichia coli at 100 μg/mL. Keywords: Amycolatopsis sp.; indole N-glycosides; SF-2140; structure reassignment; sugarnitriles

• (2) and B (3), were isolated from a sugarcane endophytic actinomycete strain Amycolatopsis sp. JS-O27 (Figure 1). This paper describes their isolation, structure elucidation, and biological investigations. Results and Discussion HPLC analysis of the MeOH extract of rice culture of Amycolatopsis sp