Beilstein J. Org. Chem.2006,2, No. 3, doi:10.1186/1860-5397-2-3
not take into account the nature and environmental impact of the generated waste. In order to arrive at a more meaningful prediction, the E-factor is multiplied by a environmentally hazardous quotient Q. For example, a Q value of 1 can be attributed to NaCl, while heavy metals can be assigned a value
new products are fully characterized. Finally, one should never forget that the combination of certain individual compounds can create a hazardous situation (e.g. exothermic reaction between acids and bases).
For assessing these hazards, a wide variety of information is readily available, such as the
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Graphical Abstract
Scheme 1:
Reduction of nitrobenzene to aniline [23]