Mixtures of monodentate P-ligands as a means to control the diastereoselectivity in Rh-catalyzed hydrogenation of chiral alkenes

• Manfred T. Reetz and
• Hongchao Guo

Beilstein J. Org. Chem. 2005, 1, No. 3, doi:10.1186/1860-5397-1-3

• using a 1:1 mixture of triphenylphosphine and a certain phosphinine (substituted phospha-benzene), 95% regioselectivity in favor of C-C bond formation at the higher substituted C-atom was achieved, whereas the use of the pure ligands as traditional homo-combinations led to low degrees of