Catalytic synthesis of (E)-α,β-unsaturated esters from aldehydes and 1,1-diethoxyethylene

• Rubén Manzano,
• Lidia Ozores,
• Andreas Job,
• Lars Rodefeld and
• Benjamin List

Beilstein J. Org. Chem. 2009, 5, No. 3, doi:10.3762/bjoc.5.3

• treatment with a suitable reagent or catalyst could readily lead to the corresponding unsaturated ester and ethanol or methanol as the only by-product. The use of ketene dialkyl acetals for organic transformations is infrequent [27]. To the best of our knowledge, they have been employed in [2+2

High stereoselectivity on low temperature Diels- Alder reactions

• Luiz Carlos da Silva Filho,
• Valdemar Lacerda Júnior,
• Mauricio Gomes Constantino,
• Gil Valdo José da Silva and
• Paulo Roberto Invernize

Beilstein J. Org. Chem. 2005, 1, No. 14, doi:10.1186/1860-5397-1-14

• unsubstituted and α- or β-methyl substituted 2-cycloenones was also observed. Introduction For more than 70 years, the Diels-Alder reaction, or [4+2] cycloaddition reaction, has remained as one of the best powerful organic transformations in chemical synthesis, particularly in obtaining polycyclic rings. Many

Cobalt(II) chloride catalyzed one-pot synthesis of α-aminonitriles

• Surya K. De

Beilstein J. Org. Chem. 2005, 1, No. 8, doi:10.1186/1860-5397-1-8

• synthesis of α-aminonitriles. In continuation of our work to develop new organic transformations, [11][12][13][14][15][16][17] I report herein that cobalt(II) chloride which acts as a mild Lewis acid might be a useful and inexpensive catalyst for the synthesis α-aminonitrile. Although cobalt(II) chloride

• has been extensively used as a mild catalyst for a plethora of organic transformations, [18][19][20] there are no examples of the use of cobalt(II) chloride as catalyst for the synthesis of α-aminonitriles. Results and discussion The treatment of benzaldehyde and aniline with KCN in the presence of a