Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

• Karunananda Bombuwala,
• Thomas Kinstle,
• Vladimir Popik,
• Sonal O. Uppal,
• James B. Olesen,
• Jose Viña and
• Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

• stacked on it in such a way that the nucleotide-binding site is embedded in the interface [8]. Ravelli and coworkers found colchicine binding site to be buried in the β subunit, boxed in by β-strands of the second domain and helices #7 and #8. The A ring of colchicine contacts residue 241[9], consistent