8-epi-Salvinorin B: crystal structure and affinity at the κ opioid receptor

• Thomas A. Munro,
• Katharine K. Duncan,
• Richard J. Staples,
• Wei Xu,
• Lee-Yuan Liu-Chen,
• Cécile Béguin,
• William A. Carlezon Jr. and
• Bruce M. Cohen

Beilstein J. Org. Chem. 2007, 3, No. 1, doi:10.1186/1860-5397-3-1

• ] The epimers can be readily identified by TLC: the unnatural compounds almost invariably spot above the natural compounds in EtOAc/hexanes, and give a blue rather than pink/purple colour when visualized with vanillin.[19] The unnatural epimers are also recognizable by their distinctive H-12 multiplet

Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

• Karunananda Bombuwala,
• Thomas Kinstle,
• Vladimir Popik,
• Sonal O. Uppal,
• James B. Olesen,
• Jose Viña and
• Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

• interest has been focused on new, highly-active classes of natural products such as the dolastatins and the cryptophycins. Such natural compounds and their synthetic derivatives have been evaluated for dosage and side effects in preliminary clinical trials [12][13][14][15], but the results do not suggest

Study of thioglycosylation in ionic liquids

• Jianguo Zhang and
• Arthur Ragauskas

Beilstein J. Org. Chem. 2006, 2, No. 12, doi:10.1186/1860-5397-2-12

• ionic liquids for the synthesis of alkyl glycoside and disaccharides via coupling of thioalkyl glycosyl donors with glycal acceptors. Alkyl glycosides and oligosaccharides are important intermediates and products in the synthesis of biologically active natural compounds and mimics. For example, tetra-O