Green oxidations: Titanium dioxide induced tandem oxidation coupling reactions

• Vineet Jeena and
• Ross S. Robinson

Beilstein J. Org. Chem. 2009, 5, No. 24, doi:10.3762/bjoc.5.24

• is known to be highly reactive under sunlight [17] and this seemed to be the most obvious starting point. Initially, 2-hydroxyacetophenone was reacted with o-phenylenediamine under natural sunlight. We were delighted to observe the formation of the quinoxaline derivative in an isolated yield of 90

The first preparative solution phase synthesis of melanotan II

• Vladimir V. Ryakhovsky,
• Georgy A. Khachiyan,
• Nina F. Kosovova,
• Elena F. Isamiddinova and
• Andrey S. Ivanov

Beilstein J. Org. Chem. 2008, 4, No. 39, doi:10.3762/bjoc.4.39

• Vladimir V. Ryakhovsky Georgy A. Khachiyan Nina F. Kosovova Elena F. Isamiddinova Andrey S. Ivanov R&D Dept., Pharm-Sintez, 38 Shosse Entusiastov, 111123 Moscow, Russia 10.3762/bjoc.4.39 Abstract Melanotan II is a synthetic cyclic heptapeptide used to prevent a sunlight-induced skin cancer by