Hydrogenation of aromatic ketones, aldehydes, and epoxides with hydrogen and Pd(0)EnCat™ 30NP

• Steven V. Ley,
• Angus J. P. Stewart-Liddon,
• David Pears,
• Remedios H. Perni and
• Kevin Treacher

Beilstein J. Org. Chem. 2006, 2, No. 15, doi:10.1186/1860-5397-2-15

• ]. For these kind of substrates, catalysts based on Ni, Pd, and Pt have been used, and further efforts are directed toward improving the chemoselectivity and regioselectivity of this ring-opening reaction. [18][19] We now demonstrate that aryl aldehydes and ketones as well as aryl epoxides can also

Synthesis and glycosidase inhibitory activity of new hexa- substituted C8-glycomimetics

• Olivia Andriuzzi,
• Christine Gravier-Pelletier,
• Gildas Bertho,
• Thierry Prangé and
• Yves Le Merrer

Beilstein J. Org. Chem. 2005, 1, No. 12, doi:10.1186/1860-5397-1-12

• afforded the corresponding azido-alcohols 11 and 12, isolated as single stereoisomers in excellent yield (95–98%). No other isomer of 11 or 12 was detected by NMR analysis, indicating that the ring-opening reaction is highly regioselective and results in the anti addition of the azido group on the opposite