Beilstein J. Org. Chem.2009,5, No. 59, doi:10.3762/bjoc.5.59
their potential receptor properties for cations, anions and neutral molecules, calixarenes have enjoyed widespread use in various areas of science and technology. One of their successful applications as sensors is in analytical chemistry. They are useful for separations, enrichment, and analyses of
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Graphical Abstract
Scheme 1:
Synthesis and structures of calix[4]arenes 6–8; 3, 6: n = 2; 4, 7: n = 3; 5, 8: n = 5.
Beilstein J. Org. Chem.2008,4, No. 37, doi:10.3762/bjoc.4.37
efficient highly diastereoselective one-step reduction of both carbonyl functions in 2 have not been realized, enrichment of one or the other diastereoisomer by choice of reducing agent is feasible and acceptable yields of pure diastereoisomers can be obtained.
Enantioselective bis-reduction of 2
Asymmetric
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Graphical Abstract
Scheme 1:
Tautomerization of 1,4-dihydroxynaphthalene.