Functionalization of heterocyclic compounds using polyfunctional magnesium and zinc reagents

• Paul Knochel,
• Matthias A. Schade,
• Sebastian Bernhardt,
• Georg Manolikakes,
• Albrecht Metzger,
• Fabian M. Piller,
• Christoph J. Rohbogner and
• Marc Mosrin

Beilstein J. Org. Chem. 2011, 7, 1261–1277, doi:10.3762/bjoc.7.147

• functionality to an azide group is readily achieved by treating 81 with NaN3/BF3·OEt2-CF3CO2H in CH2Cl2 leading to the aryl azide 82 in 78% yield. Heating of 82 in mesitylene at reflux for 6 h provides ellipticine 83, a potent antitumor agent in 57% yield (Scheme 14) [42]. The structural variations of

Calix[4]arene-click-cyclodextrin and supramolecular structures with watersoluble NIPAAM-copolymers bearing adamantyl units: “Rings on ring on chain”

• Bernd Garska,
• Monir Tabatabai and
• Helmut Ritter

Beilstein J. Org. Chem. 2010, 6, 784–788, doi:10.3762/bjoc.6.83

• -dipropargylether-26,28-hydroxy-calix[4]arene (calix[4]arene-1,3-dipropargylether) (2) onto 6I-azido-6I-deoxycyclomaltoheptaose (3) was proven by IR spectroscopy by the disappearance of the bands for the azide group at 2105 cm−1 and for the propargyl group at 2115 cm−1, whilst the formation of the triazole ring was

Synthetic incorporation of Nile Blue into DNA using 2′-deoxyriboside substitutes: Representative comparison of (R)- and (S)-aminopropanediol as an acyclic linker

• Daniel Lachmann,
• Sina Berndl,
• Otto S. Wolfbeis and
• Hans-Achim Wagenknecht

Beilstein J. Org. Chem. 2010, 6, No. 13, doi:10.3762/bjoc.6.13

• visible spectrum) for use in “click” conjugation have been reported meanwhile [18]. The dye carrying the azide group was reacted with an alkyne group that was incorporated into the oligonucleotides as a nucleotide substituent. (S)-3-Amino-1,2-propanediol was used as an acyclic linker and substitute for

Functional properties of metallomesogens modulated by molecular and supramolecular exotic arrangements

• Alessandra Crispini,
• Mauro Ghedini and
• Daniela Pucci

Beilstein J. Org. Chem. 2009, 5, No. 54, doi:10.3762/bjoc.5.54

• depend on the size of the X group and on the dipole moment associated with the Pt-X bond, with the sequence, for the clearing points Clazide group which promoted a lowering of both transition temperatures. Moreover, these Pt(II) complexes revealed to be photoluminescent with a good degree

Acid- mediated reactions under microfluidic conditions: A new strategy for practical synthesis of biofunctional natural products

• Katsunori Tanaka and
• Koichi Fukase

Beilstein J. Org. Chem. 2009, 5, No. 40, doi:10.3762/bjoc.5.40

• alternative to the N-phthalyl function, we also employed the C-5 azide group in sialyl donor 1b because this azide group should direct similar “fixed-dipole moment effects”, but should be easier to convert to naturally occurring N-substituents of neuraminic acids, i.e., N-acetyl or N-glycolyl groups (see