Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica

• Lu Zou,
• Ruixiang Blake Zheng and
• Todd L. Lowary

Beilstein J. Org. Chem. 2012, 8, 1219–1226, doi:10.3762/bjoc.8.136

• Lu Zou Ruixiang Blake Zheng Todd L. Lowary Alberta Glycomics Centre and Department of Chemistry, The University of Alberta, Edmonton, AB T6G 2G2, Canada 10.3762/bjoc.8.136 Abstract A series of methoxy and deoxy derivatives of mannopyranose-1-phosphate (Manp-1P) were chemically synthesized, and

• the Alberta Glycomics Centre, the University of Alberta and the Natural Sciences and Engineering Research Council of Canada. We thank Dr. Warren Wakarchuk at the National Research Council of Canada for providing the plasmid containing the GDP-ManPP gene, and Mr. Myles B. Poulin for technical

The use of glycoinformatics in glycochemistry

• Thomas Lütteke

Beilstein J. Org. Chem. 2012, 8, 915–929, doi:10.3762/bjoc.8.104

• aid with quality control. Specific problems of glycoinformatics compared to bioinformatics for genomics or proteomics, especially concerning integration and long-term maintenance of the existing glycan databases, are also discussed. Keywords: carbohydrates; databases; glycomics; software

• resources have also been started. Formats and protocols for data exchange have been specified [9][10]. Recently, the MIRAGE (Minimum Information Related to A Glycomics Experiment) consortium was founded to define checklists for the standardization of experimental glycomics data and meta information [11

• weekly with new PDB entries. Other databases that implemented CarbBank data are KEGG GLYCAN [35], EUROCarbDB [24], and the Glycan Structure Database of the Consortium for Functional Glycomics (CFG) [21]. KEGG GLYCAN is part of the Kyoto Encyclopedia of Genes and Genomes (KEGG) and integrates carbohydrate

Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations

• Baptiste Thomas,
• Michele Fiore,
• Isabelle Bossu,
• Pascal Dumy and
• Olivier Renaudet

Beilstein J. Org. Chem. 2012, 8, 421–427, doi:10.3762/bjoc.8.47

• viruses or bacteria [2][3][4][5]. In a suitable density and spatial display, clusters of carbohydrate indeed allow multiple contacts with a target protein, thus increasing avidity by means of the “glycoside cluster effect” [6][7]. While the recent progress in glycomics has led to the design of

Synthesis in the glycosciences II

• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2012, 8, 411–412, doi:10.3762/bjoc.8.45

• to assemble as the oligosaccharides. And there is no other cell organelle that is less understood in its detailed biochemical function and the meaning of its supramolecular identity than the glycocalyx. Hence, the field of “glycomics” may comprise a rather infant field of the “omics era”, but it is