Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

• Karunananda Bombuwala,
• Thomas Kinstle,
• Vladimir Popik,
• Sonal O. Uppal,
• James B. Olesen,
• Jose Viña and
• Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

• residue 205, forms a Rossmann fold in which parallel β-strands alternate with four α-helices. The next domain contains five helices and a mixed β-sheet, one strand of which is contiguous to the β-sheet in the amino-terminal domain. Nogales and coworkers showed that the α-subunit resembles the β- and is