TY - JOUR A1 - Li, Yue A1 - Wang, Feng A1 - Liu, Li A1 - Ning, Rui A1 - Kong, Dulin A1 - Wu, Mingshu T1 - Base-Catalyzed Diastereoselective Construction of Spiro-epoxyoxindoles  by the Darzens Reaction of 3-Chlorooxindoles with Aryl Aldehydes under Solvent-free Grinding JF - Beilstein Archives Y1 - 2022/// SN - M3 - doi:10.3762/bxiv.2022.44.v1 N2 -  A highly efficient, diastereoselective strategy for the synthesis of aryl-substituted spiro- epoxyoxindole derivatives by a Darzens-type reaction of α-chlorooxindoles with aryl aldehydes in the presence of bases under solvent-free grinding conditions has been developed. The process features with easy work-up, mild reaction condition, high to excellent diastereoselectivitie and yields as well as environmental compatibility. ER -