TY - JOUR A1 - Odens Jr., Herman H. A1 - You, Jae Y. A1 - Gallimore, Alexandria D. A1 - Palm, Preston H. A1 - Davis, Cameron W. A1 - Bahena, Josue M. A1 - Moser, Jeffrey S. A1 - Smith, Mackenzie E. A1 - Odens, Herman H. T1 - Novel one-pot synthesis of 2-thio-substituted-3-H-phenothiazin-3-ones driven by oxidation with sodium periodate JF - Beilstein Archives Y1 - 2022/// SN - M3 - doi:10.3762/bxiv.2022.36.v1 N2 - A series of novel 2-thio-substituted-3H-phenothiazin-3-ones (6h-l) was effectively synthesized in one pot after optimization of the four-step synthesis.  Treatment of a 2-alkylthio-1,4-benzoquinone (3a-l) made in situ and condensed with 1,2-aminothiophenol (5) followed by oxidation with NaIO4 produced the desired final targets. A four-step reaction sequence in which 1,4-benzoquinone (1) is first reacted with an alkylthiol (2a-l) in the presence of sodium periodate (NaIO4) and then treated with 2-aminothiophenol (5) followed by a second oxidation with sodium periodate was demonstrated to be effective in synthesizing 2-thio-substituted-3H-phenothiazin-3-ones (6a-g). The one-pot synthesis is an improvement of the stepwise synthesis of these 2-thio-substituted-3H-phenothiazin-3-one heterocycles since four steps are run in sequence and treated as one. ER -