TY - JOUR A1 - Ma, Xiaoming A1 - Meng, Suzhi A1 - Zhang, Xiaofeng A1 - Zhang, Qiang A1 - Yan, Shenghu A1 - Zhang, Yue A1 - Zhang, Wei T1 - Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3+2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions JF - Beilstein Archives Y1 - 2020/// SN - M3 - doi:10.3762/bxiv.2020.28.v1 N2 - Two kinds of [3+2] cycloadditions intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for one-pot N-allylation and intramolecular Heck reactions to form pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines. The multicomponrnt reaction was combined with one-pot reactions to make the synthetic method with good pot, atom and step economy. MeCN was used as a preferable green solvent for the reactions.    ER -