TY - JOUR A1 - Karuo, Yukiko A1 - Kametani, Ayaka A1 - Tarui, Atsushi A1 - Sato, Kazuyuki A1 - Kawai, Kentaro A1 - Omote, Masaaki T1 - Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers mediated by a reaction between phenols and halothane JF - Beilstein Archives Y1 - 2020/// SN - M3 - doi:10.3762/bxiv.2020.21.v1 N2 - An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibited a broad reaction scope, simple operation, and no need for any expensive transition-metal catalysts, or highly toxic reagents. Notably, we demonstrated the potential utility of halothane for obtaining such aryl gem-difluoroalkyl ethers containing a bromochloromethyl group. ER -