TY - JOUR A1 - Więcław, Michał Mateusz A1 - Furman, Bartłomiej T1 - Direct synthesis of anomeric tetrazolyl iminosugars from sugar-derived lactams JF - Beilstein Archives Y1 - 2020/// SN - M3 - doi:10.3762/bxiv.2020.118.v1 N2 - Herein we present the direct asymmetric synthesis of tetrazole-functionalized 1-deoxynojirimycin derivatives from simple sugars via a Schwartz’s reagent-mediated reductive amide functionalization followed by a variant of the Ugi-azide multi-component reaction. The anomeric configurations of two products were unambiguously confirmed by X-ray analysis. This work also describes examples of interesting further transformations of the title products. Finally, some surprising observations regarding the mechanism of their formation were made. ER -