TY - JOUR A1 - Lin, Qiao A1 - Zhang, Shiling A1 - Li, Bin T1 - KOtBu Promoted Selective Ring-Opening N-alkylation of 2-Oxazolines to Access 2-Aminoethyl Acetates and N-Substituted Thiazolidinones JF - Beilstein Archives Y1 - 2019/// SN - M3 - doi:10.3762/bxiv.2019.146.v1 N2 - An efficient and simple KOtBu promoted selective ring-opening N-alkylation of 2-methyl-2-oxazoline or 2-(methylthio)-4,5-dihydrothiazole with benzyl halides under basic conditions has been described for the first time, which provides a convenient and practical pathway for the synthesis of versatile 2-aminoethyl acetates and N-Substituted thiazolidinones with good functional group tolerance and selectivity. KOtBu not only plays an important role to promote this ring-opening N-alkylation, but also acts as an oxygen donor. ER -