TY - JOUR A1 - Rusnac, Roman Vasile A1 - Botnaru, Maria Stefan A1 - Barba, Nicanor A1 - Petrenko, Peter Alexei A1 - Chumakov, Yurii A1 - Gulea, Aurelian Petru T1 - NOVEL COMPOUNDS FROM CONDENSATION REACTION BETWEEN 2-ACETYLPYRIDINE AND 2-FORMYLPYRIDINE. SYNTHESIS, CRYSTAL STRUCTURE AND BIOLOGICAL EVALUATION JF - Beilstein Archives Y1 - 2019/// SN - M3 - doi:10.3762/bxiv.2019.145.v1 N2 - Two new carbonyl compounds (5-6) were synthesized and spectrally characterized. The reaction mechanism for obtaining the new carbonyl compounds (5-6) was proposed following the analisis retrosintetis reactions of the products and confirmed by 1H and 13C-NMR. Synthesized carbonyl compounds (3-6) can serve as precursors (carbonyls) in the synthesis of thiosemicarbazones, which exhibit a wide range of biological properties. Due the condensation reaction between 2-acetylpyridine and 2-formylpyridine, catalysed with Na2CO3 in aqueous solution and microwave irradiation at 480 W, the product 1,3-bis(pyridin-2-yl)prop-2-en-1-one (3) in a good yield is obtained. By separation on the silica gel column, three products (4-6) were removed. Characterization of novel condensation products between 2-acetylpyridine and 2-formylpyridine was performed by FTIR-ATR spectroscopy, 1H and 13C-NMR spectroscopy, and further confirmed by single crystal X-ray diffraction. Compound (5) crystallise in the space group P-1 and compound (6) in the space group P21/c. Based on the spectral data and X-ray crystallography analysis of the eliminated products, the succession of reactions resulting in compounds (3-6) from (1) and (2) were proposed. Finally, synthetic methods for the preparation of substituted cyclohexanol derivatives have also been proposed. The obtained compounds exhibit moderate antimicrobial and antifungal activity. Antioxidant activity of compounds (4-6) was also studied. ER -