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[null,"Supporting Information for: Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)"]
[null,"Allison S. Limpert, Margrith E. Mattmann, and Nicholas D. P. Cosford*"]
["#","Structure ","Name","Alias","Reference","Target/Mechanism"]
[1,"Structure2","6-(trifluoromethoxy)benzo[d]thiazol-2-amine","riluzole ","McDonnel, Vera et al., 2012","Reduction of glutamate signaling"]
[2,"C10H17N3S","(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine","dexpramipexole","Glicksman, 2012; Dunkel et al., 2012","Mitochondrial stabilizer"]
[3,"C14H20ClN3O3","(R,Z)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide","arimoclomol","Glicksman, 2012; Dunkel et al., 2012","Heat-shock protein co-inducer"]
[4,"C27H45NO","(8S,9S,10R,13R,14S,17R,E)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one oxime","olesoxime","Glicksman, 2012; Dunkel et al., 2012","Mitochondrial pore modulator"]
[5,"C18H18N8O7S3","(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid","ceftriaxone","Glicksman, 2012; Dunkel et al., 2012","Inducer of the glial glutamate transporter (GLT1, EAAT2)"]
[6,"C10H10N2O","3-methyl-1-phenyl-1H-pyrazol-5(4H)-one","edaravone","Glicksman, 2012; Dunkel et al., 2012","Free radical scavenging agent"]
[7,"Structure4","3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4H-chromen-4-one","052C9","Murakami, Inuoe et al., 2011","Reduction in SOD1 Expression by decreased phosphorylation of Nrf2"]
[8,"Structure5","N-(4-(4-(4-methylbenzoyl)piperazin-1-yl)phenyl)thiophene-2-carboxamide",7687685,"Wright, Wightman et al., 2012","Reduction in SOD1 Expression"]
[9,"Structure6","5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine","pyrimethamine","Wright, Huang et al., 2010","Reduction in SOD1 Expression"]
[10,"Structure7","5-((4-chloro-2,5-dimethylphenylthio)methyl)-1H-pyrazol-3(2H)-one","ASP/AOP Series","Benmohamed, Arvanites et al., 2011","Reduce cellular toxicity and mutant SOD1 protein aggregation"]
[11,"Structure8","5-(4-fluorophenyl)cyclohexane-1,3-dione","CHD Series","Benmohamed, Arvanites et al., 2011","Reduce cellular toxicity and mutant SOD1 protein aggregation"]
[12,"Structure9","1-(2-cyclohexenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione","PYT Series","Benmohamed, Arvanites et al., 2011","Reduce cellular toxicity and mutant SOD1 protein aggregation"]
[13,"Structure10","5-((3,5-dichlorophenoxy)methyl)-1H-pyrazol-3(2H)-one","ASP/AOP Series","Chen, Benmohamed et al., 2012","Reduce cellular toxicity and mutant SOD1 protein aggregation"]
[14,"Structure11","5-(3,5-bis(trifluoromethyl)phenyl)cyclohexane-1,3-dione","CHD Series","Zhang, Benmohamed et al., 2012","Reduce cellular toxicity and mutant SOD1 protein aggregation"]
[15,"Structure12","(S)-5-(1-(3,5-bis(trifluoromethyl)phenoxy)ethyl)cyclohexane-1,3-dione","CHD Series","Zhang, Benmohamed et al., 2012","Reduce cellular toxicity and mutant SOD1 protein aggregation"]
[16,"Structure13","1,3-diphenethylpyrimidine-2,4,6(1H,3H,5H)-trione","PYT Series","Xia, Benmohamed et al., 2012","Reduce cellular toxicity and mutant SOD1 protein aggregation"]
[17,"C8H14CuN6S2","Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone)","Cu(II)(atsm)","Parker, Meyerowitz et al. 2012","Prevent TDP-43 aggregation"]
[18,"C26H29NO","(Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine","tamoxifen","Wang, Guo et al. 2012","Induce autophagy"]
[19,"C15H12N2O","5H-dibenzo[b,f]azepine-5-carboxamide","carbamazepine","Wang, Guo et al. 2012","Induce autophagy"]
[20,"C7H19N3","N1-(3-aminopropyl)butane-1,4-diamine","spermidine","Wang, Guo et al. 2012","Induce autophagy"]
[21,"C52H81NO13","(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]-oxaazacyclohentriacontine-1,5,11,28,29 (4H,6H,31H)-pentone","rapamycin","Wang, Guo et al. 2012","Induce autophagy"]
[22,"Structure16","(S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-(4-(4-(4-fluorobenzyl)phenyl)piperazin-1-yl)propan-2-ol","SUN N8075","Shimazawa, Tanaka et al., 2010","Potentiation of VGF upregulation in response to cell stress"]
[23,"C13H13NO3","4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid ","A844131.2","Van Hoecke, Schoonaert et al. 2012","Inhibition of Epha4"]
[24,"C21H16Br2FN2","N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline","P7C3A20","Pieper, Xie et al. 2010","Neuroprotection"]
[25,"C13H16O2","DL-3-n-butylphthalide","DL-3-n-butylphthalide","Feng, Peng et al. 2012","Neuroprotection"]
[26,"Structure17","4,4',4''-(ethane-1,1,1-triyl)tris(2,6-diethoxyphenol)","AGS-499","Eitan, Tichon et al., 2012","Increased telomerase expression"]
[27,"Structure18","1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea","AR-A014418","Koh, Kim et al., 2007","GSK-3 Inhibition"]
[28,"Structure20","(4aS,6aR,6bS,8aR,12aR)-N-ethyl-11-isocyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxamide","CDDO-EA","Neymotin, Calingasan et al., 2011","Nrf2 signaling upregulation"]
[29,"Structure21","(4aS,6aR,6bS,8aR,12aR)-11-isocyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-N-(2,2,2-trifluoroethyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxamide","CDDO-TFEA","Neymotin, Calingasan et al., 2011","Nrf2 signaling upregulation"]
[30,"Structure19","2-(mesityloxy)-N-(5-(pyridin-2-yl)thiazol-2-yl)acetamide","CPN-9","Kanno, Tanaka et al., 2012","Reduction of oxidative stress"]
[31,"C18H19ClN4","3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H-pyrrolo[2,3-b]pyridine","L-745,870","Okada, Sakai et al. 2005","Upregulate neuronal apoptosis inhibitory protein (NAIP)"]
[32,"C32H40BrN5O5","2-bromo-12′-hydroxy-5′-(2-methylpropyl)-3′,6′,18-trioxo-2′-(propan-2-yl)ergotaman","bromocriptine","Tanaka, Kanno et al. 2011","Upregulate neuronal apoptosis inhibitory protein (NAIP)"]
[33,"C10H11NaO2","sodium phenylbutyrate ","PBA","Ryu, Smith et al. 2005","HDAC inhibitor"]
[34,"C17H22N2O3","7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide","trichostatin A","Yoo and Ko. 2011","HDAC inhibitor"]
[35,"C2H2Cl2O2","dichloroacetate","DCA","Miquel, Cassina et al. 2012","Improve glial mitochondrial function"]
[36,"C19H30O2","dihydrotestosterone"," DHT ","Yoo and Ko 2012","Neuroprotection"]
[37,"C19H28O2","dehydroepiandrosterone","DHEA","Hayes-Punzo, Mulcrone et al. 2012","Neurosteroid"]